CLINICAL TRIALS AND OBSERVATIONS Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
نویسندگان
چکیده
Anthony V. Moorman,1 Christine J. Harrison,1 Georgina A. N. Buck,2 Sue M. Richards,2 Lorna M. Secker-Walker,1 Mary Martineau,1 Gail H. Vance,3 Athena M. Cherry,4 Rodney R. Higgins,5 Adele K. Fielding,6 Letizia Foroni,6 Elisabeth Paietta,7 Martin S. Tallman,8 Mark R. Litzow,9 Peter H. Wiernik,7 Jacob M. Rowe,10 Anthony H. Goldstone,11 and Gordon W. Dewald, on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group12
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993
1University College London, London, United Kingdom; 2Rambam Medical Center and Technicon, Israel Institute of Technology, Haifa, Israel; 3Clinical Trial Service Unit, Oxford, United Kingdom; 4Northern Institute for Cancer Research, Newcastle University, Newcastle, United Kingdom; 5Bristol Haematology and Oncology Centre, Bristol, United Kingdom; 6Nottingham University, Nottingham, United Kingdo...
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We examined the prognostic impact of cytogenetics on the outcome of 200 acute lymphoblastic leukemia (ALL) patients 15 to 65 years of age enrolled in Southwest Oncology Group (SWOG)–9400 study. Evaluable cytogenetics or fluorescence in situ hybridization studies were available in 140 (70%) patients. Four karyotype categories (normal [n 31, 22%], t(9;22)/BCR/ABL1 [n 36, 26%], other unfavorable [...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
1Department of Medical and Molecular Genetics, King’s College London School of Medicine and Department of Haematology, Guy’s & St. Thomas’ NHS Foundation Trust, London; 2Department of Haematology, Cardiff University School of Medicine, Cardiff; 3Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne; 4Department of Haematology, U...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
The international acute lymphoblastic leukemia (ALL) study was designed to prospectively define the optimal therapy for adults 60 years of age or younger with newly diagnosed ALL. All patients received identical induction therapy, and 91% achieved complete remission (CR). Patients 50 years of age or younger with a compatible sibling were assigned to undergo allogeneic transplantation; the other...
متن کاملMedical Research Council adjuvant trial in high-grade gliomas.
Working Party has reported a phase III comparative trial of radiother-apy with adjuvant versus no adjuvant chemotherapy with procarbazine, lomustine, and vincristine (PCV) in patients with high-grade gliomas. 1 At the time of study design, PCV was considered to be potentially the best standard of care, although the superiority of this regimen over single-agent nitrosourea has recently been ques...
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